The Yazoo City Indians fell to 2-4 on the season after suffering a 42-8 loss to Class 4A No. 2 ranked Louisville last Friday.
The Indians, 2-4, fell behind early and never could find their footing in the lopsided loss.
The Wildcats scored two touchdowns early in the contest and led 14-0 at the close of the first quarter.
Louisville continued to pour it on in the second period, scoring 21 unanswered points to take a 35-0 lead into the half.
They would add one more score in the third quarter and the Indians scored their lone touchdown in the fourth on a 15-yard pass from freshman QB Marquez Taylor to Kamari Taylor.
The Indians had a dismal offensive showing rushing for just 88 yards (Deon Johnson 59, Marquez Taylor 29) and passing for just 15 yards.
Yazoo City hopes to find a win this Friday when they travel to district foe Greenwoood.